Cialis has been sold worldwide since 2003. It was the drug manufacturer Eli Lilly who developed Cialis and today is a very strong competitor for Viagra. The biggest difference between Viagra and Cialis is that Cialis has an effect lasting about 36 hours while Viagra lasts about four hours.
Cialis (tadalafil), like sildenafil, is a selective inhibitor of phosphodiesterase with the indication erectile dysfunction. As with sildenafil, sexual stimulation requires that the drug is effective. The proportion of responders in clinical trials, i.e. Patients who recovered normal erectile abilities were 10.9% in placebo groups, while 39.7% and 58.6% in the 10 and 20 mg tadalafil groups respectively. The drug has a long half-life, which means that the effect can last for 24-36 hours. The drug has been shown to be effective in patients with diabetes. However, no studies have been performed on patients with central nervous system disorders or have undergone different types of surgery in the pelvis.
Cialis effect duration that makes it unique
Tadalafil is the second selective inhibitor phosphodiesterase for the treatment of erectile dysfunction. The efficacy compared to sildenafil has not been clarified but appears to be similar. A difference compared to sildenafil is that tadalafil has longer efficacy time. The significance of this for safety has not been clarified. Another difference is that the effect of tadalafil, in contrast to the case of sidafil, has not been documented in patients with neurological damage such as spinal cord injury or in patients who have undergone various forms of surgery in the pelvis.
As stated above, the biggest difference between Viagra, Cialis and Levitra is that they have different long-lived effects. Cialis has effect up to 36 hours which is 32 hours longer than Viagra and Levitra, Cialis is also called the weekend game.
In order for an ED drug to give effect, you need to be sexually excited to get an erection. Over 80% of those who test Cialis have experience potent results of restored erectile function. Cialis works within 30 minutes and lasts about 36 hours.
Most men choose Cialis in front of Viagra because Cialis has less effect on the other body, which may feel milder.
A functioning erection is a basis for a good sex life and positively influences relationships. As men have a better potency, their self-confidence increases when using Cialis or Viagra. Cialis has affected more than 80% of men with erection problems. Tadalafil is the active substance found in Cialis.
The function that Cialis provides is that the muscles around the swelling bodies of the penis relax and increase blood flow to the penis, resulting in erection. If you are 18 years old and experience erection problems, you can order Generic Cialis online from us at My Canadian Pharmacy (view offer page: http://www.mycanadianpharmacygroup.com/generic-cialis). There are only a few who have experienced side effects. Cialis is most appropriate if you are taking other medicines.
All drugs give some side effects. Most people who take ED drugs are not affected by any side effects. The side effects listed below have only been found a few times. Nasal congestion, headache, indigestion, back pain, hives, flushing, muscle pain, swollen eyelids are listed by the developer as possible side effects to Cialis use.
Cialis can be purchased in 10mg or 20mg. We recommend 10 mg initially because there are lower side effects. If you do not get the result you want, try 20mg. After about 30 minutes you will notice the effect of Cialis, which lasts for up to 36 hours when you are sexually excited.
What is Cialis half life?
In sexual stimulation, a localized release of nitrogen oxide occurs in the erectile tissue of the penis, which stimulates guanyl cyclase activity. This raises the intracellular concentration of cyclic guanosine monophosphate (cGMP) that relaxes the smooth muscle in the blood vessels. This leads to increased blood flow in the penis and erection. Inhibitors of phosphodiesterase 5 reduce the degradation of cGMP thereby enhancing the response to the release of nitrogen oxide. Phosphodiesterase inhibitors have no effect in the absence of sexual stimulation.
In 1998, the first oral drug was approved for erectile dysfunction, sildenafil, a selective inhibitor of phosphodiesterase 5. Now, an additional selective inhibitor of phosphodiesterase 5, tadalafil, has been approved.
A pharmacokinetic difference between tadalafil and sildenafil is that tadalafil has a half-life of 17.5 hours in healthy subjects, while sildenafil is approximately four hours.
Dose effect studies have been conducted at doses ranging from 2-100 mg tadalafil. In all studies, fixed doses were tested in parallel groups. No dose titration studies have been conducted to attempt to highlight treatment response at higher doses in patients who did not have adequate effect of 10-20 mg. Based on the outcome of the dose-effect studies, doses of 10 and 20 mg were tested in phase III studies.
Six placebo-controlled parallel group studies have been conducted. In three of the studies, tadalafil was given in the recommended doses of 10 and 20 mg. All studies began with a treatment-free period of four weeks to determine the erectile function and sexual function at the base level. Patients were instructed to take the drug as needed regardless of the expected sexual activity. The effect was evaluated after twelve weeks in six studies, (interim report in one) and after six months in a study. A total of 1,113 patients were included in the six studies.
The study population consisted of men over 18 years of age in a stable monogamous relationship with female partners who had had at least three months of erectile dysfunction. Patients who used nitrates or had an unstable heart disease including unstable angina, heart failure or uncontrolled hypertension were excluded. In a study, patients with diabetes mellitus were included. Patients suffering from erectile dysfunction due to spinal cord injury or other neurological damage, as well as prostatectomized patients or pelvic surgery or trauma patients were excluded or studied to a limited extent, therefore the efficacy of these patients is not known.
The drug effect was evaluated using two questionnaires. IIEF (International Index of Erectile Dysfunction) is a questionnaire that evaluates the patient’s perception of the erectile function in the last four weeks. The total score may vary from 1 to 30. A score >26 is considered normal erectile function.
The SEP Diary (Sexual Encounter Profile) is a questionnaire filled in by the patient shortly after each sexual intercourse attempt. SEP has five questions, the answers should be yes or no.
The primary effect measure was composed of three variables that illuminated the erectile function. The one highlighted function in the last four weeks (IIEF domain erectile function), the second and third were SEP Question 2 (Could you insert your penis into your partner’s vagina?) And 3 (If your erection is long enough to make you could carry out a successful intercourse?).
Make it or break it things affecting Cialis results
The major benefit of Cialis compared to other erectile drugs (Viagra, Levitra) is the long-term effect. Since it is not necessary to take this erectile pills right before sexual intercourse, your sex life becomes a natural character again. But for Cialis effects to be their best, a few simple rules should be observed.
Cialis can be ordered in 10 mg and 20 mg packagings. The tablets 5 mg and 2.5 mg are called Cialis Once a Day. Always follow the doctor’s advice when using this erectile agent. Cialis 10 mg and 20 mg take at least 30 minutes before you have sex. After ingestion, this drug is still active for 36 hours. You can experience sex without problems during these 36 hours. The variant Cialis Once a Day is taken every day at a fixed time, which gives you a continuous effect. It is not recommended to use Cialis in combination with alcohol. This can have a negative influence on the effect. Use Cialis 10 mg, 20 mg, 5 mg and 2.5 mg no more than 1 time a day.
Note: Cialis is not intended for men under 18 years or for women. If you are taking other medicines, tell your doctor. It is possible that the combination with Cialis gives interaction.
If you use your Cialis pills with regard to the safety rules, you will observe the following benefits:
Normal sex life. Unlike other erectile pills, the effect of Cialis is about 17 to 36 hours. That is also why it is also called the weekend puzzle. With Cialis you do not need to ‘plan in’ sex and can therefore have spontaneous intercourse. You then get the feeling of having an erection in a natural way. Cialis only has effect when you become sexually stimulated;
Available in different dosages. Cialis can be ordered at Dokteronline.com in 2.5 and 5 mg (this is the ‘Once a Day’ variant), 10 mg and 20 mg. By testing on different dosages (start with a low dose), you prevent side effects such as headache and pain in the back;
Longer and faster effect. In addition to the long lasting effect, you notice the effect of Cialis after 15 minutes. It’s faster than ‘colleague’ Viagra.
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